But until now, they haven’t understood why this happens. Scientists know that gametocyte formation is triggered when local levels of a lipid-related molecule called lysophosphatidylcholine (lysoPC) are low, as occurs in human bone marrow. falciparum), can spread from infected humans back to mosquitoes, completing their transmission cycle, only after they change from the asexual form that is responsible for the disease into sexual forms known as gametocytes. The findings may help scientists develop new ways to prevent malaria from spreading. ![]() A key developmental step in the lifecycle of the most virulent species of malaria parasite depends in part on a series of molecular signals, detailed in a new study led by researchers at Weill Cornell Medicine.
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